Meet the Exeter team

Anna Murray

Anna Murray works in the field of reproductive genomics. She is particularly interested in discovering genetic variants associated with reproductive lifespan that can further our understanding of the biological processes involved. The group also use genetic variants associated with traits such as menopause timing as instruments to make causal inferences for outcomes such as breast cancer and type II diabetes. Other projects are using a combination of genomic and non-genetic risk factors to predict women at increased risk of early menopause.  

Kate Ruth

My work has included carrying out genome-wide analyses of reproductive traits including reproductive lifespan, menstrual cycle length and sex hormone levels. In these studies we investigate correlations between genetic variation and phenotypes by analysing data in many thousands of people. Applying these genomic methods provides an opportunity to improve our understanding of the biology of such traits and our knowledge of how different disorders are related to each other. We can also use the genetic signals found by our studies to identify reproductive disorders that cause, rather than are correlated with, health outcomes. I am also interested in how we can use routinely collected health data to explore the genetic basis of reproductive traits, for example, by analysing data from big population-based studies with linked health data like UK Biobank. For example, my previous work highlighted that lower follicle stimulating hormone levels are linked to longer menstrual cycle length and that there are overlaps with the genetics of other reproductive traits.

Jess Tyrrell

Jess Tyrrell uses genetics to research the complex links between metabolic health and mental health. Depression and mental health problems are more prevalent in women. Some studies have suggested links between menstrual health and mental health in women, although these relationships remain poorly understood. We are using genetic methods to test the relationship between a number of menstrual factors (e.g. sex hormones, menarche age and menopause age) and well validated mental health outcomes, including treatment resistant depression.

Julia Prague

I am an NHS Consultant in Endocrinology, Diabetes, and General Internal Medicine at the Royal Devon and Exeter Hospital and Honorary Senior Clinical Lecturer at the University of Exeter. My PhD was in reproductive endocrinology and particularly focused on the menopause and finding a new treatment for menopausal vasomotor symptoms that avoids the side effects of HRT.

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